Legend Biotech Highlights Recent Business Updates at 44th Annual J.P. Morgan Healthcare Conference

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• Patients treated earlier, after one or two prior lines of therapy, exhibited greater immune fitness and a more immunocompetent tumor microenvironment, potential biological indicators of longer progression-free survival

  80% confidence

• CARVYKTI cemented its status as the undisputed leader in multiple myeloma CAR-T cell therapy, with its continued record-breaking performance culminating in the achievement of more than 10,000 patients treated earlier this year

  80% confidence

• We're also committed to leveraging our proven CAR-T development platform to frontline multiple myeloma and promising new in vivo and allogeneic opportunities to extend our leadership in cell therapy innovation

  80% confidence

• Targeting multiple investigational new drug (IND) filings for oncology and autoimmune indications starting in second half 2026

  80% confidence

• Expect company-wide operating profit in 2026

  80% confidence

• Anticipate CARVYKTI franchise FY 2025 profitability

  80% confidence

• First-in-human data for in vivo dual CD20/CD19 therapy expected starting in the second half of 2026

  80% confidence

• The latest NCCN guidelines recommend talquetamab as a bridging therapy before CAR-T treatment for people with relapsed/refractory multiple myeloma to help keep patients eligible for CARVYKTI and improve outcomes

  80% confidence

• The Company believes cash and cash equivalents, and time deposits of approximately $1.0 billion as of September 30, 2025, will provide financial runway beyond 2026

  80% confidence

• Triple-class-exposed patients treated with three prior lines of therapy from the CARTITUDE-1 and CARTITUDE-4 trials achieved a median progression-free survival of 50.4 months following a single infusion of CARVYKTI

  80% confidence

• Legend Biotech is poised for transformative growth in 2026, as we work to achieve profitability this year by driving global adoption of CARVYKTI

  80% confidence